Late survival time of patients with ovarian cancer may be related to T-cell-related
【Medical Industry Network Docguide.com2003 years, according to Houston, January 14 Reuters new study findings show that women suffering from ovarian cancer, whether it can survive after the immune system's T cells, which play an important role. The researchers believe that this conclusion to the current through the strengthening of the body's defense mechanisms within the cancer effort is a kind of support, they speculated that ovarian tumor T-cells may help doctors predict the prognosis and guide treatment. At present the U.S. with advanced ovarian cancer patients survive five years, less than 25%.
The study published in the "New England Journal of Medicine" (TheNewEnglandJournalofMedicine2003; 348:203-213), it was found that in those women suffering from advanced ovarian cancer, the tumor cells are T cells than those without the cells are able to live 3 times the time; but also in the right surgery and chemotherapy response in women, cancer cells are T cells can have more time to live 10 times. T cells can help arrange the body's overall immune response, and directly attacking foreign objects, infections, and cancer cells. Author, University of Pennsylvania, the ancient Kos (GeorgeCoukos) explains, they believe that if T-cell therapy can "infiltration" into the tumor, we can form a strong immune response and long-term work.
He told Reuters that they want to use a immune-enhancing therapies - such as cancer vaccines - to enhance the patient's T cell response, or let those who had failed to respond to re-react. He and colleagues in 186 patients with advanced ovarian cancer samples taken before treatment. It was found that tumors containing T cells of women survived for five years, 38%, but not T cells were only 4.5%. Previous studies have shown that some ovarian tumors contain T cells, but do not quite understand its meaning. And this new study, the survival time of this contact with the patient up. In addition, many other tumors have also saw the same link, such as melanoma, breast, prostate and colon cancer.
Based on the above conclusions, the authors estimate that half of the tumors in patients with advanced ovarian cancer exist in T cells. But to understand why only half of the people, but an important issue. In addition, they also noted that ovarian cancer in the presence or absence of T cells may also be used to predict the prognosis of patients. "We found a very important and not previously known prognostic indicators," said the ancient Kos.
