Which factors of gastric cancer patients
(A) environmental factors, the incidence of different countries and regions of significant difference between the description and environmental factors, foremost among which is the dietary factors.
Salt may be induced by exogenous factors of gastric cancer, one of the residents of salt intake and more countries have a high incidence of gastric cancer. Nitrosamine compounds have been successfully induced gastric cancer in animals. Smoked fish contain more 3,4 - benzopyrene (benzopyrene); moldy food contains more of the fungal toxin; rice covered with talcum powder after processing outside, its chemical properties and structure are related to asbestos fibers similar to the above-mentioned material were considered to have carcinogenic effects.
(B) the genetic factors in some families a higher incidence of gastric cancer. Some data indicate that gastric cancer occurred in blood group A person who is more than the O blood type.
(C) the immune factors when people with low immune function in a higher rate of gastric cancer may be immune dysfunction, cancer, immune to the decline in the supervisory role, in gastric cancer have a certain sense.
(D) pre-cancerous changes in the so-called pre-cancerous change is that some have a strong tendency to malignant lesions, such lesions if not dealt with, there may develop into gastric cancer. Precancerous changes include pre-cancerous condition (precancerous conditions) and pre-cancerous lesions (precancerous lesions).
1. Gastric precancerous condition
(1) chronic atrophic gastritis: chronic atrophic gastritis and gastric cancer incidence was significantly positively correlated.
(2) pernicious anemia: pernicious anemia patients, 10% of gastric cancer, gastric cancer incidence of the normal population of 5 ~ 10 times.
(3), gastric polyp: adenoma, or villous polyps although the total proportion of gastric polyps in a high cancer rate was 15% ~ 40%. Greater than 2cm in diameter were higher cancer rates. Hyperplastic polyps more common, while the cancer rate of only 1%.
(4) remnant stomach: gastric remnant stomach after surgery of benign lesions occurred in remnant gastric carcinoma, said. The stomach after surgery, especially in the beginning after 10 years, incidence increased significantly.
(5), benign gastric ulcer: gastric ulcer in itself is not a pre-cancerous state. The edge of the mucosal ulcers are prone to intestinal metaplasia and malignant transformation.
(6) large gastric folds syndrome (Menetrier's disease): Serum protein leakage through the huge folds of gastric mucosa, clinically hypoproteinemia and edema, about 10% of cancer.
2. Gastric precancerous lesions
(1) and between dysplastic change: the former is also known as atypical hyperplasia, chronic inflammation caused by the reversible pathological cell proliferation, a small number of cancer cases can not happen. Gastric change (anaplasia) were cancerous opportunities.
(2) intestinal metaplasia: There are two kinds of intestinal-type and large intestine type, intestinal type (complete type) has the characteristics of small intestinal mucosa, differentiation better. Coliform (incomplete type) and the colorectal mucosa are similar can be divided into two subtypes: Ⅱ a type, can secrete the non-sulfated mucin; Ⅱ b-type can be secreted sulfated mucin, closely related to the type and occurrence of gastric cancer .
