The pathogenesis of central nervous system lymphoma
Time:2009-11-05 13:49 Author:admin Hits:
The central nervous system, non-lymphatic circulation and lymph nodes, there are three causes of lymphoma, an early theory that the lymphoma originated in the leptomeningeal blood vessel cells, the membrane-week post-invasion and extended into the adjacent brain tissue around the perforator vascular space, violating the deep structure of the hemisphere . The second doctrine, lymphoma, non-tumor reactive lymphocytes in the central nervous system caused by clustering. The lymphatic system due to the lack of brain tissue mononuclear inflammatory cells were relatively low, the immune function of brain tissue is relatively weak, in chronic antigen stimulation of the immune system in the form of polyclonal anti-antigen should be further stimulated lymphocyte proliferation may occur the formation of specific gene mutations and develop into a monoclonal proliferation of malignant lymphoma of the third doctrine, other than the lymph nodes or lymph node B lymphocytes develop into tumors, tumor cells with the blood circulation to migrate, because of their cell surface markers to bring the central nervous system-specific adsorption things, so that only gathered in the central nervous system, while the true primary site is unclear, this theory can explain the multiple intracranial lymphoma.
Pathogenesis:
Lymphoma can occur in any part of the central nervous system, but most occurred in the screen, the approximately 50% of the lymphoma occurred in the cerebral hemisphere, posterior fossa accounted for 10% to 30% supratentorial, 18% involved simultaneously, lesions occur in the basal ganglia, corpus callosum, periventricular white matter and cerebellar vermis, soft meninges, choroid plexus, and septum pellucidum also often involved. Brain lymphoma, for focal lesions, or diffuse infiltrative growth of tumor no envelope. Focal placeholder can be multiple, often located near ventricles, for physical diseases, ill-defined texture can be soft around the obvious edema can be hard, blood supply is rich in white or purple. Very little bleeding and cystic necrosis. The general concept of diffuse tumor growth may be normal, may have expanded subarachnoid space, resulting in the thickening was gray, it belongs to B-cell lymphoma, small cell and large cell type were more common.
Microscopy showed diffuse infiltration of tumor cells, far beyond the borders in general, cell density, little cytoplasm, Duocheng round or oval nuclei and clear, variable length or distortion, chromatin are many and scattered, more common phenomenon of nuclear fission, sometimes sleeve-like tumor cells were distributed along the blood vessels surrounding and sometimes can also be found within the brain tissue around the tumor-like lesions showed the distribution of nests of tumor cells, and even away from the tumor within the brain tissue can also be seen scattered or clustered distribution of tumor cells, which may constitute a multi-center, or tumor recurrence based on tumor blood supply abundant, mostly below the middle level of the small blood vessels. Leptomeningeal involvement occurs in the autopsy rate is about 12%.
Pathogenesis:
Lymphoma can occur in any part of the central nervous system, but most occurred in the screen, the approximately 50% of the lymphoma occurred in the cerebral hemisphere, posterior fossa accounted for 10% to 30% supratentorial, 18% involved simultaneously, lesions occur in the basal ganglia, corpus callosum, periventricular white matter and cerebellar vermis, soft meninges, choroid plexus, and septum pellucidum also often involved. Brain lymphoma, for focal lesions, or diffuse infiltrative growth of tumor no envelope. Focal placeholder can be multiple, often located near ventricles, for physical diseases, ill-defined texture can be soft around the obvious edema can be hard, blood supply is rich in white or purple. Very little bleeding and cystic necrosis. The general concept of diffuse tumor growth may be normal, may have expanded subarachnoid space, resulting in the thickening was gray, it belongs to B-cell lymphoma, small cell and large cell type were more common.
Microscopy showed diffuse infiltration of tumor cells, far beyond the borders in general, cell density, little cytoplasm, Duocheng round or oval nuclei and clear, variable length or distortion, chromatin are many and scattered, more common phenomenon of nuclear fission, sometimes sleeve-like tumor cells were distributed along the blood vessels surrounding and sometimes can also be found within the brain tissue around the tumor-like lesions showed the distribution of nests of tumor cells, and even away from the tumor within the brain tissue can also be seen scattered or clustered distribution of tumor cells, which may constitute a multi-center, or tumor recurrence based on tumor blood supply abundant, mostly below the middle level of the small blood vessels. Leptomeningeal involvement occurs in the autopsy rate is about 12%.
