Salinomycin kill breast cancer stem cells, good results

Recently, foreign experts found that: salinomycin right culling wonders of breast cancer stem cells, and this addition of a number of rehabilitation in patients with breast cancer.

Breast cancer stem cells are in a class, it can rule against the traditional method, therefore, destruction of these stem cells can more easily treat cancer. Foreign researchers said they found chemicals salinomycin can kill breast cancer stem cells, research published in the August 13 "cell" magazine.

Massachusetts Institute of Technology Pew disabilities Gupta, led the research, he said, there are many evidence that cessation of treatment, breast cancer stem cells will lead to cancer.

He also noted that cancer stem cells are rare and difficult to study in the laboratory, because they will soon become other types of cells, and it is difficult to kill them.

To study these cancer stem cells, Gupta, the team first found a way to cancer stem cells in the laboratory will be stabilized, and allow them to copy, then, the researchers used 16,000 kinds of chemical substances to test these cells were observed which kinds of compounds to kill these cancer stem cells.

Among them 32 compounds stand out, the researchers then screened out as part of compounds, and in mice in the experiment.

It was found that a compound called salinomycin the ability to kill breast cancer stem cells than conventional chemotherapy drugs such as paclitaxel 100 times stronger.

Were treated with paclitaxel compared to cancer stem cells, after salinomycin-treated cancer stem cells are injected into mice, the cause of breast cancer risk is much smaller, and the mice tumor growth speed significantly slowed down.

Gupta said there was still not confirm, salinomycin to kill breast cancer stem cells, the best compounds, it is not clear that the use of these drugs in humans is safe. However, the research for the pharmaceutical companies to provide a new direction of development, they can isolate and test compounds to kill these cells.

The researchers also said that the treatment of cancer can be two-pronged approach: on one hand the eradication of tumor cells; the other hand, manufacture of tumor cells to eradicate the system, while the common treatment methods can not eliminate the latter.